Mariko Hashimoto Selected Research

9- (5',5'- difluoro- 5'- phosphonopentyl)- 9- deazaguanine

4/2010

9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.

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Mariko Hashimoto Research Topics

Disease

4	Neoplasms (Cancer) 04/2013 - 01/2008
2	Osteonecrosis (Kienbock's Disease) 04/2013 - 04/2011
2	Suppuration 04/2013 - 04/2011
2	Lymphoma (Lymphomas) 04/2010 - 04/2010
1	Cysts 01/2023
1	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2023
1	Autoimmune Diseases (Autoimmune Disease) 04/2010
1	Diarrhea 06/2009
1	Glaucoma 02/2004

Drug/Important Bio-Agent (IBA)

2	Diphosphonates (Bisphosphonates)IBA 04/2013 - 04/2011
1	Tolvaptan FDA Link 01/2023
1	HypoxanthineIBA 04/2010
1	9-deazaguanineIBA 04/2010
1	difluoromethaneIBA 04/2010
1	9- (5',5'- difluoro- 5'- phosphonopentyl)- 9- deazaguanineIBA 04/2010
1	phosphonic acidIBA 04/2010
1	GuanineIBA 04/2010
1	Immunosuppressive Agents (Immunosuppressants)IBA 04/2010
1	Purine-Nucleoside PhosphorylaseIBA 04/2010
1	Antiviral Agents (Antivirals)IBA 06/2009
1	SteroidsIBA 06/2009
1	diphenylmethaneIBA 06/2009
1	Latanoprost (Xalatan)FDA Link 02/2004
1	isopropyl unoprostone (Rescula)FDA Link 02/2004
1	Timolol (Blocadren)FDA LinkGeneric 02/2004
1	Betaxolol (Kerlon)FDA LinkGeneric 02/2004
1	dorzolamide (Trusopt)FDA LinkGeneric 02/2004
1	Ophthalmic Solutions (Eye Drops)IBA 02/2004

Therapy/Procedure

3	Therapeutics 01/2023 - 04/2011
2	Radiotherapy 04/2013 - 04/2011
2	Duration of Therapy 04/2013 - 04/2011
1	Liver Transplantation 01/2008
1	Laparoscopic Cholecystectomy 01/2008
1	Operative Surgical Procedures 01/2008